No sooner had Isaac Newton received his university degree, in 1665, then the plague came, which forced everyone to leave Cambridge.
A) As soon as Isaac Newton received his university degree in 1665, people had to abandon Cambridge because of the outbreak of the plague.
B) Upon being forced to leave Cambridge due to the plague in 1665, Isaac Newton received his university degree.
C) Before Isaac Newton finished university in 1665, the plague had broken out in Cambridge and made people leave the city.
D) The plague forced everyone including Isaac Newton, who would soon receive his university degree, to leave Cambridge in 1665.
E) It was 1665 when Isaac Newton had to leave Cambridge with his university degree since the plague afflicted everyone.