The destructive effects of spending extended periods of time cut off from society have been recognised for centuries, if not

The destructive effects of spending extended periods of time cut off from society have been recognised for centuries, if not thoroughly understood.
A) People may seclude themselves from others for long periods of time although they realise that it might have adverse impacts; however, the reasons behind this practice have not been clearly explained for centuries.
B) For centuries, we have been struggling to find out why certain people keep themselves away from the public for a considerable amount of time and whether its impacts are detrimental
C) Separating yourself from other people for lengthy periods of time is thought to have harmful consequences that have been observed but remain uninvestigated for centuries.
D) While the devastating impacts of isolating yourself from the public for long periods of time have not been fully comprehended, they have been acknowledged for centuries.
E) It has been accepted for centuries that alienating yourself from the public can lead to damaging consequences, but why this may last for a long time has not been examined in detail.